44. Type 2 diabetes I. can develop due to a mutation in the insulin receptor II.

Question

44. Type 2 diabetes I. can develop due to a mutation in the insulin receptor II. can develop in individuals with insulin resistance. III. results in hypersensitivity to insulin release IV. are treated with drugs that decrease AMPK activity A) , II, IV C) I1, IV D) III, IV E) L, IV During prolonged starvation the majority of the stored caloric energy comes from fat stores. Which of the following provides the second largest caloric energy total? 45. A) B) C) D) E) muscle glycogen liver glycogen blood glucose muscle protein All are approximately equal. 46. Which of the following are characteristics of metabolic syndrome? I. insulin resistance Il. inflammation III. increased risk for type 1 diabetes. IV. hypersensitivity to insulin E) Ionly and produce a(an) in AMPK 47. Metformin and thiazolidinediones (TZDs) are used to treat activity A) type 2 diabetes; decrease B) type 2 diabetes; increase C) type I diabetes; decrease D) type I diabetes; increase E) both type 1 and type 2 diabetes; decrease

Explanation / Answer

Answer 44

Option B is correct i.e " I and II".

Explanation

In Type 2 diabeties , body cannot utilize the insulin properly due to the mutation in insulin receptor and it leads to the development of insulin resistance. Type 2 drugs increases the AMPK activity.

Answer 45

Option D is correct i.e " Muscle protein".

Explanation

Muscle protein is used as a preferential source of energy after 5 -15 days of starvation. Muscle protein is broken down to give carbon source that can be utilize by the liver for the synthesis of glucose by gluconeogenesis.

Answer 46

Option E is correct i.e " Insulin resistance".

Explanation

Metabolic syndrome is a variety of metabolic risk factors that come together in an individual. It includes insulin resistance, hypertension, cholesterol abnormalities and increase the risk of blood clotting.

Answer 47

Option B is correct i.e " Type 2 diabeties and it increases the AMPK activity".

Explanation

Metformin and thiazolidinediones (TZDs) are used to treat type 2 diabetes and these drugs are activators of AMPK.

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