Reactions above show the conversion of pyruvate to PEP. This is a key regulatory
ID: 269248 • Letter: R
Question
Reactions above show the conversion of pyruvate to PEP. This is a key regulatory point in which cycle? _______________
This process requires:
1) pyruvate carboxylase to convert pyruvate to _________ and PEP carboxykinase (PEPCK) to convert oxaloacetate to _________.
Would glucose level increase/decrease (circle one) if an inhibitor of pyruvate carboxylase were present?
What about levels of citrate? Increase/decrease/no effect?
PO2 o O CH2-C-C-O Phosphoenol pyruvate carboxylase? 0 PEPCK CH3-C-C-O- -o-c-CH2-C-?-0 Pyruvate Hco+ATP ADP+Pi Oxaloacetate GDP+co2 pyruvate (PEP) GTPExplanation / Answer
In the cycle of gluconeogenesis
1) oxaloacetate, phosphoenolpyruvate
If inhibitor of carboxylase is present then the conversion of pyruvate to phosphoenolpyruvate would not take place.It takes place in a series of two steps pyruvate to oxaloacetate by pyruvate carboxylase and oxaloacetate to phosphoenolpyruvate by PEP carboxykinase.
Citrate level would be increased in case of gluconeogenesis.Citrate stimulates bisphosphatase.converts fructose-1,6 bisphosphate to fructose-6- phosphate.
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