(8 pts) D-mannose can be converted to ethanol and carbon dioxide in some organis
ID: 269115 • Letter: #
Question
(8 pts) D-mannose can be converted to ethanol and carbon dioxide in some organisms. h addition to the glycolytic enzymes, the enzyme phosphomannose isomerase is used converts mannose 6-phosphate to fructose 6-phosphate. If mannose is converted to ethanol and CO, by the most direct pathway, which of the compounds and cofactors shown below are involved? Provide an explanation for each compound or cofactor you select. A) lactate B) acetaldehyde C) acetyl-CoA D) FAD E) glucose-6-phosphate F) fructose-1-phosphate G) pyruvate H) lipoic acid I) thiamine pyrophosphate J) dihydroxyacetone phosphate (10 pts) The bacteria, Ecoli, can grow under conditions where glucose is its only carbon source. Explain how it can obtain ribose-5-phosphate, which is needed for the synthesis of nucleotides (including ATP) under these conditions? (Don't describe ATP or nucleotide synthesis, just outline how ribose 5-phosphate can be synthesized.) Show structures and indicate where cofactors participate.Explanation / Answer
Answer 1)
Glucose ---> glucose 6phosphate---> fructose 6phosphate--> glucose 1-3 big phosphate ---> pyruvate
Pyruvate --->pyruvate decarboxylase--->acetaldehyde ----->alcohol dehydrogenase ---->ethanol
Answer 2)
A) glucose 6phosphate dehydrogenase is oxidized to 6 phosphogluconolactone with reduction of NADP+ to NADPH
B) lactonase the lactone ring is then oxidize to form 6 phosphogluconic acid
C) 6phosphogluconate dehydrogenase is oxidized decarboxylated to yield ribulose 5 phosphate carbon dioxide and NADPH
D) ribulose 5phosphate is isomerized to ribose 5 phosphate (R5P) an end product.
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