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DNA microarray analysis of the patterns of mRNA abundance in different human cel

ID: 264690 • Letter: D

Question

DNA microarray analysis of the patterns of mRNA abundance in different human cell types shows that the level of expression of almost every active gene is different. The patterns of mRNA abundance are so characteristic of cell type that can be used to type human cancer cells of unknown tissue origin. By definition, however, cancer cells are different from their non cancerous precursor. How do you súppose then that patterns of mRNA expression can be used to determine the tissue source of a human cancer?

Explanation / Answer

DNA microarray analysis of the patterns of mRNA abundance in different human cel