6 A) Which of the following statements regarding PI-3 kinase signaling is NOT tr

ID: 262745 • Letter: 6

Question

6 A) Which of the following statements regarding PI-3 kinase signaling is NOT true?

Loss of function mutations in PTEN cause excessive PI-3K signaling and are found in many human cancers.

The basis for PKB inactivity in unstimulated cells is conformational self-inhibition.

PI-3 kinase generates PI 3-phosphate signaling molecules after recruitment to the membrane by binding of its SH2 domain to activated receptors.

Activated protein kinase B promotes apoptosis by phosphorylating the transcription factor FOXO3a.

6 B) Which signaling pathway can be activated by cytokines?

JAK/STAT and PI-3 kinase

Ras/MAP kinase

All of the answers are correct.

JAK/STAT

PI-3 kinase

Question 6 A

The basis for PKB inactivity in unstimulated cells is conformational self inhibhition.

Question 6B

All of the answers are correct

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