MINDTAP Aplia Assignment: Gene Expression Due Today at 11 59 PM EDT 8. Single ba
ID: 260534 • Letter: M
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MINDTAP Aplia Assignment: Gene Expression Due Today at 11 59 PM EDT 8. Single base pair mutations responsible for human disorders Tay-Sachs diseese is a rare neurological disorder characterized by a deterioration of mental and physical abilities Tay-Sachs disease is caused by mutations in the HEXA gene, which encodes a subunit of a lysosornal digestive enzyme that breaks down certain lipids. Over 78 distinct HEXA mutations have been reported to cause Tay-Sachs disease, athough some mutations are mare common than others. The typical wild-type (healthy) alele and one of the disease alieles are depicted here. pairs within the protein-coding region of the gene are shown. Assume that the remainder of the me between the two alleles gene Wild-type HEXA allele Disease-causing HEXA allele 3' 5 5 3 ACC From what is shawn of their sequences, how is the disease-causing HEXA allele difterent from the wild-type atele? O It has the same number of base pairs, but one base pair is different. O it is missing a bese pair. O It contains a transposon. O I contains ani extra base pair. The tollowing are the nudeotide sequences of the mRNA codon of the disease-causing transcrpt by completing the blank. transcripts encoded by each allele. Tdentify the missing A wild-bvae mRNA transcrint O Type here to searchExplanation / Answer
Desease causing HEXA allel different from the wild type allele because it missing a base pair (@ third codon first base pair).
In second problem the stop codon is UGA ( refer first problem in which base pair is missing and change in codon frame)
The disease causing hexa allele must be result of frameshift mutation( when any base pair is miss in sequence then in translation codon frame is complete using base pair of next codon frame that is reason behind it as frameshift mutation
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