3. The diagram below outlines the endocytic pathway for cholesterol uptake in th

Question

3. The diagram below outlines the endocytic pathway for cholesterol uptake in the cell. Your you to design a mutation in one of the components in the pathway that will prevent up a component to mutate and explain how changing the sequence in your protein wi cholesterol (how it interrupts the pathway). take of cholesterol. Pick ll prevent uptake of LOL-LDL receptors plasma membrane CYTOSOL ENDOCYTOSIS clathrin coated vesicle RETURN OF LDL RECEPTORS TO PLASMA MEMBRANE UNCOATING endosome BUDDING OFF OF TRANSPORT VESICLES FUSION WITH ENDOSOME TRANSFER TO LYSOSOME free cholesterol hydrolytic enzymes ysosome

Explanation / Answer

only question 3 is answered here.

from the given data, LDL-receptor protein encoding gene has to be mutated in order to prevent the uptake of cholesterol. if this gene is mutated, the information that is present in this gene will get changed. if the information in the DNA is changed, then the m-RNA transcribed using this changed DNA also gets changed. and accordingly the the sequence of the protein that is made out of this changed information also gets changed.

If the sequence of the protein is changed, then the tertiary structure of the protein LDL-receptor also gets changed. when the structure changes its function of binding with cholesterol also gets changed. Thus, the uptake of cholesterol is prevented.

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