There is a specific protein found in the inner mitochondrial membrane called the

ID: 258921 • Letter: T

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There is a specific protein found in the inner mitochondrial membrane called the ATP-ADP translocase. It provides the path for ATP to leave the matrix and go into the cytoplasm and for ADP to enter the matrix from the cytoplasm. Which of the following is true regarding this process? Choose TWO correct answers.) Note: This is a challenge question for you to practice answering using your logic and knowledge of proteins and membrane transport. The answers are not found in your textbook! The translocase will also provide a path for pyruvate to enter the matrix The translocase is required because ATP and ADP cannot pass through lipid bilayers . ? The translocase has a higher affinity for ATP when it is "open" toward the matrix The translocase moves ATP against its concentration gradient

Explanation / Answer

Answer: Option 2 and 3 are correct

ADP/ATP translocase is a transporter protein transports ATP produced by oxidative phosphorylation into the cytosol and thus involved in many metabolic processes

In the given options, option 1 is not true since ATP-ADP translocase do not provide path for pyruvate to enter the matrix. Translocase recognises only natural nucleotides ATP and ADP. Hence, option 1 is wrong

Option 2 which states that translocasse is required because ATP, ADP cannot pass through lipid bilayers. This is true because ATP and ADP have high negative charge making them impermeable to lipid membrane. Thus Translocase acts as antiporter that couples the transport of the ATP and ADP.

Option 3 is also correct because Translocase alternatively faces the matrix and cytosol and it bind with the ATP from the matrix by eversion and later release ATP into transmembrane space which is later diffused into cytoplasm

Option 4 is incorrect because ATP movement is not in terms of concentration. The movement is energetically unfavorable but compensated by antiporting ADP and ATP.

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There is a specific protein found in the inner mitochondrial membrane called the

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