Figures 2 and 3 in Storz (2007)show sharp rise oxygen saturation early on in the

Question

Figures 2 and 3 in Storz (2007)show sharp rise oxygen saturation early on in the sigmoidal curves. What is the property of hemoglobin accounts for the shape of this curve?

O2 mmol-L-1 Oxygen partial pressure (kPa) 12 16 100 80 Hb-02 affinity 4 increased 16 Torr 26 Torr 9 60 normal Other mammals -decreased 36 Torr o 40 A- Vicuña Llama 20 40 Po,, Torr 20 FiG. 2.-Theoretical influence of a change in hemoglobin-oxygen affinity on the oxygen dissociation curve under moderate hypoxia (open symbols) and severe hypoxia (closed symbols). The y-axis measures the oxygen concentration in whole blood (Co,) and the x- axis measures the partial pressure of oxygen (Po.). The symbols labcled with arrows denote the valucs for mixed venous blood, and thc unlabeled symbols denote values for arterial blood. For clarity differences in arterial-mixed-venous oxygen concentrations are oxygen dissociation curves. At a given level of hypoxia, note how changes in hemoglobin-oxygen affinity 0 20 40 60 80 100 120 Oxygen partial pressure (mm Hg) FIG. 3. The oxygen dissociation curves of llamas and vicuñas are left-shifted relative to the curves of other terrestrial mammals that are not physiologically adapted to chronic hypoxia. The left-shifted curves are attributable to the fact that these 2 high-altitude specics have identical in each of the 3

Explanation / Answer

The property of cooperative binding on haemoglobin with oxygen as we know a single haemoglobin can accommodate 4 oxygen molecules. when first oxygen binds to haemoglobin its affinity for the next oxygen in increased significantly this is followed till the last oxygen molecule after which its affinity for oxygen decreases giving it a sigmoidal shape

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