10 A) Which of the following statements about phospholipase C signaling is true?
ID: 258031 • Letter: 1
Question
10 A) Which of the following statements about phospholipase C signaling is true?
It cleaves an inositol derivative into membrane-associated IP3 and diffusible DAG.
Upon GPCR activation, GDP is replaced by GTP on the G-alpha subunit, which directly activates phospholipase C.
DAG and IP3 are intimately involved in intracellular Na+ signaling.
The substrate of phospholipase C is inositol.
10 B) Of the components of a heterotrimeric G protein, which subunit is able to activate downstream responses?
only the ? subunit
only the ? subunit
only the ?/? subunits
both the ? subunit and the ?/? subunits
Explanation / Answer
Please find the answers below:
Answer 10A: Choice 2 (Spontaneous phosphorylation of membrane bound GDP to GTP remains one of the critical steps of GPCR signalling driven by phospholipase C enzymatic activity)
Answer 10B: Choice 1 (During the sequential set of reactions, the alpha subunits remains the one which catalyzes the downstream signalling events in the cytoplasm such as activation of enzymes and other siganlling molecules, whereas the beta and gamma subunits remain bound to the heterotrimeric G protein in the plasma membrane)
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