please answer all 3 questions 1. Imagine that a cell with four chromosomes was t
ID: 255816 • Letter: P
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please answer all 3 questions
1. Imagine that a cell with four chromosomes was treated with Monastrol in late G2. In the space provided, draw what you would expect the cell to look like in prometaphase Oncologists often prescribe several different chemotherapy drugs in combination. The idea is that tumor cells are less likely to escape the toxicity if they are being hit from several directions at once, and they also might be less likely to develop resistance to the drugs. Imagine you are an oncologist planning to treat a cancer patient with Vincristine, and you want to prescribe a second drug that will target a different aspect of the cell cycle. Which drug would you pick, and why? 2. Phalloidin is a mushroom-derived toxin that prevents the depolymerization of actin. It is currently primarily used in microscopy to label the actin in cells for biomedical research. However, imagine that Phalloidin was developed into a chemotherapy drug. What stage of the mitotic (M) phase would be targeted by Phalloidin, and why? (HINT: What stage might involve cycles of actin polymerization and depolymerization?) 3. Copyright O2016 Pearson Education, Inc.Explanation / Answer
Ans 2. The anticancer agent cytolenin A which is a fusicoccane diterpene glycoside can be considered as a potent agent for treatment of cancer. It posses synergistic effect with vincristine. It has been found useful for the treatment of multiple myeloma. It induces apoptosis in such cells. by the synergistic effect. It functions by formation of LC3-II and degradation of p62 protein.
Ans 3. Phalloidin functions by stabilization of nuclei resulting in polymerisation of actin and its stabilization. Actin polymerisation adn rearrangement occurs in the meta phase. Hence the activity of phalloidin would occur in the metaphase.
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