8 pts. The drug dideoxycytidine, used to treat certain viral infections and show

Question

8 pts. The drug dideoxycytidine, used to treat certain viral infections and shown below on the right, is a nucleotide made with 2,3'-dideoxyribose. AZT is another antiviral pictured below, left. Use your knowledge of DNA replication to explain why both of these drugs are able to stop the growth of a DNA chain when added to a virally-infected cell that making DNA.Note: both drugs act in the same way. Answer onl DNA replication. The answer is really only a sentence or two long and should fit between the pictures and the line. ly the question asked. Please don't tell me about normal NH2 HN ? HO-P-O-P-0-P-O ??-?-?-?-?-?-?- OH OH OH 1 ? ?? ?? ??

Explanation / Answer

Dideoxycytidine -inhibits DNA synthesis by blocking the 3'-ends in DNA replication fork which reduce the rate of chain elongation at the replication fork. Where as AZT inhibits the activity of an enzyme called reverse transcriptase which stop it from making new virus .

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