Thioamide drugs can be determined by cathodic stripping analysis.30 Deposition o

Question

Thioamide drugs can be determined by cathodic stripping analysis.30 Deposition occurs at +0.05 V versus an SCE. During the stripping step the potential is scanned cathodically, and a stripping peak is observed at –0.52 V. In a typical application a 2.00-mL sample of urine was mixed with 2.00 mL of a pH 4.78 buffer. Following a 2.00 min deposition, a peak current of 0.562 A was measured. A 0.10-mL addition of a 5.00 M solution of the drug was added to the same solution. A peak current of 0.837 mA was recorded using the same deposition and stripping conditions. Report the drug’s molar concentration in the urine sample.

Explanation / Answer

time=2 min I=0.562micro

charge=0.562*2*60*10^-6=0.00006744

molar concentration=number of moles/volume =

moles=5/0.10=50microM

molar concentration=50microM/2=25microM

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