This pedigree shows inheritance of black and orange coat coloring in domestic ca

Question

This pedigree shows inheritance of black and orange coat coloring in domestic cats controlled by a single gene on the X chromosome with two alleles: Xo and Xb. XoXo females and and XoY males are orange; XbXb females and XbY males are black. XoXb females are calico with patches of black and orange fur. The gel image shows alleles of a microsatellite marker locus on the X chromosome–gel lanes are aligned with the corresponding individual in the pedigree above. a. Why do males always have one band while females sometimes have one and sometimes two? b. Which microsatellite marker is associated with orange coat color? c. Which individuals have progeny that provide information aboutrecombination frequency? d. Assuming that the allele coupled to Xb is the same in #14 and 15, what recombination frequency between the coat color gene and the marker is indicated by these data? e. Bonus: Why are some females calico? 14 15 calico calt 9 10 11 12 13 112131?16?7?81??????16-1 718LILIP122237

Explanation / Answer

a.Men always have one band while females have one or two bands. Because the marker used in this study belongs to X-chromosome. Males would have only one X-chromosome. Whereas, females have two X-chromosomes. two of them may be same (XoXo or XbXb) or different (XoXb). Based on these differences, they may have one or two bands.

b. microsatellite marker ‘A’ is associated with orange coat colour.

c. individuals 4,5, 19 and 20 have progeny that provide information about recombination frequency.

d. I guess the recombination frequency is 1/9 or 10%

e. some females are calico because they contain the genes for both orange coat colour and black color and they co-dominant. (XoXb)

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