As a healthy adult with no history of prior heart attack, you are invited by mai

Question

As a healthy adult with no history of prior heart attack, you are invited by mail to participate in an upcoming clinical trial which aims to evaluate the effect of daily baby aspirin on the risk of heart attack. You learn that you will either be randomly assigned to a daily baby aspirin of a particular dose (ow, medium, or high), or to tak (placebo). You will not know your treatment assignment. There will be free physical exams twice per by a physician at your convenience, at which your health status will be assessed, including if you experienced an cardiovascular symptoms or a heart attac which will be provided to you by mail free of charge. your part besides taking the pill In your opinion. do you think there is a scientific rationale to conduct this study? If you think there is one, explain why. If not, describe why you think the science does not support a need for the study (no need for citations) In a general sense, and assuming all participants provide consent, does this study seem ethical? Why or why not We all have different motivations to participate (or not) in scientific rese and, even if participating in an experimental study is definitely not your cup of tea, please engage in this discussion from a hypothetical perspective. arch. Respect the viewpoint of your peers Now, reflecting back on what you have learned from your assigned module readings, please respond to the remainder of the discussion questions You've learned from the notes and readings that experimental studies have tremendous value in the epidemiologic community, but also that they might not always be feasible or otherwise have some important limitations. We will now engage in a discussion to practice developing an experimental study to address a particular research question. To do this, it is useful to think in terms of limitations: whether a study will take too long or cost too much, whether it is ethical, whether blinding can sufficiently be maintained, and so on. The goal is to use a variety of novel examples (generated by each of you!) to better understand when and how experimental studies should be conducted Participate in the discussion by developing a response to the questions below in an articulate and thorough way . Propose a research question you think can be addressed by an experimental study (use your imagination, it doe not have to be a drug trial), and present your question articulately. Be sure that your treatment assignment and health outcomes of interest are clearly stated Identify the population you would recruit to answer the question (i.e., the group of people you would invite participate) and what groups of people you would exclude Address aspects of blinding, randomization, compliance, and loss to follow-up in YOUR study (please do not provide generic language from the notes and readings Happly it to your study). This means you should think

Explanation / Answer

Science does not support need for such a study because most of the experiments can now be done without having test subjects i.e. producing similar conditions in vitro.So,there would not be any use of test subjects.

It is ethically incorrect as the healthy test subjects might develop increased risk of heart attack and actually suffer a heart attack in course of time as they are being subject to aspirin doses.

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