Glycogen Metabolism Q.2 Predict the effect of a duplication of the gene for phos

Question

Glycogen Metabolism Q.2 Predict the effect of a duplication of the gene for phosphorylase kinase in mutant liver cells relative to normal liver cells that only contain a single copy of the gene. O A Glycogen synthase activity would be higher in the mutant cells. O BThe rate of glycolysis would be increased in mutant liver cells. OCThe ratio of unphosphorylated/phosphorylated glycogen phosphorylase would be higher in mutant cells. O DThe activity of glycogen phosphorylase will be increased in the mutant cells.

Explanation / Answer

The Answer is D: The activity of glycogen phosphorylase will be increased in the mutant cells.

By the duplication of the gene Phosphorylase kinase in Mutant liver cells, there must be another copy of a Phosphorylase kinase will present which means, more amount of Phosphorylase kinase will be translated. As Phosphorylase kinase is a regulatory enzyme in the activation cascade of glycogenolysis. By phosphorylating and thus activating glycogen phosphorylase, Phosphorylase Kinase stimulates glycogen degradation in response to various neural and hormonal signals.

That means, there will be no relation between Glycogen synthase and Phosphorylase kinase because of Phosphorylase kinase activate Glycogen phosphorylase. So, we can omit Option A and the process of Glycogen degradation is known as glycogenolysis, that's why we can also omit the Option B.

Phosphorylase kinase phosphorylates glycogen phosphorylase that means the phosphorylated enzymes would be much higher in the amount of the mutant cells rather than the unphosphorylated one. So, Option C is omitted.

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