4. Cancer is a disease characterized by uncontrolled cellular accumulation of mu

Question

4. Cancer is a disease characterized by uncontrolled cellular accumulation of mutations in the tumor cell. This can result in specific immunogenic tumor-associated antigens (TAA, or neoantigens) in the tumor cell that generate an immune response very much like non-self antigens. A. (16pts.) A patient is suffering from late-stage melanoma (skin cancer). Briefly describe an experimental approach that identifies specific TAA (neoantigen) proteins, peptides or epitopes in this patient's tumor cells. B. (4pts.) Using the TAA you identified (in A, above), provide an idea about how could you use the TAA to develop a personalized immune therapy against the patient's tumor cells?

Explanation / Answer

We can identify the neoantigen TAA present on the surface of the meloma by developing antibodies against that particular antigen using Agglutination process. Immunopercipitation reaction is helpful in identifying the peptide antigen as the surface molecules.

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