Looking at these two pictures, which would produce a larger effect on cell ATP p
ID: 211324 • Letter: L
Question
Looking at these two pictures, which would produce a larger effect on cell ATP production, a problem with complex 1 (NADH-Q reductase complex) or a problem with protein complex 2 (succinate dehydrogenase). Why? Electrons from NADH are accepted by NADH-Q reductase at the start of the electron transport chain. Electrons also come from succinate by way of FADH these electrons are accepted by 5 NADH FADH Succinate dehydrogenase. 40 NADH-Q reductaseUbiquinone (C) complex Cytochrome c reductase 30 F Cytochrome c 9 20 Cytochrome c oxidase complex 1Explanation / Answer
If we inhibit complex1 less ATP will be produced.
As we know that NADH2 produces 2.5 ATP and FADH2 produces only 1.5 ATP. So, it will cause more loss if we inhibit complex 1.
NADH produces 3 ATP during the ETC (Electron Transport Chain) with oxidative phosphorylation because NADH gives up its electron to Complex I, which is at a higher energy level than the other Complexes. When Complex I transfers the electron to Complex III, energy is given off to pump protons across the membrane, creating a gradient. The electron moves again to Complex IV and again pumps more electrons across the membrane. Because NADH started with Complex I, it had more chances to pumps more protons across the gradient, which powers the ATP synthase and gives us 3 ATP per molecule of NADH. FADH2 produces 2 ATP during the ETC because it gives up its electron to Complex II, bypassing Complex I. By bypassing Complex I, we missed a chance to pump protons across the membrane, so fewer protons have been pumped by the time we get to Complex IV. Protons still have been pumped, enough to fuel 2 ATP created by ATP synthase.
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