The poison cyanide binds to the last complex of the electron transport chain and

Question

The poison cyanide binds to the last complex of the electron transport chain and prevents it from accepting electrons. Assuming this is the only effect of cyanide what will be the primary effect of cyanide on aerobes (cells that require oxygen)?

Glycolysis stops; Citric acid cycle stops; electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2.

Citric acid cycle stops; electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis continues.

Electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis and Citric acid cycle continue.

Oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis, Citric acid cycle, and the electron transport chain continue.

Electrons are not transfered to O2. Everything else continues.

Glycolysis stops; Citric acid cycle stops; electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2.

Citric acid cycle stops; electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis continues.

Electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis and Citric acid cycle continue.

Oxidative phosphorylation stops; electrons are not transfered to O2. Glycolysis, Citric acid cycle, and the electron transport chain continue.

Electrons are not transfered to O2. Everything else continues.

Explanation / Answer

Option 1 is correct.

Glycolysis stops; Citric acid cycle stops; electron transport stops; oxidative phosphorylation stops; electrons are not transfered to O2. Cyanide inhibits the final step in the electron transport chain by binding with cytochrome c oxidase. Being blocked, it stops the whole process of making water, and stops the protons (H+) from translocating across the membrane to create a chemical gradient. This then stops the H+ ions from diffusing back through the ATP synthase which creates ATP.
Cyanide overall stops the Link Reaction, Krebs Cycle and Election Transport Chain. If the electron transport chain is blocked, then the electron carriers NADH and FADH2 cannot unload their electrons into it, which means NAD+ and FAD are not regenerated. Since glycolysis and the Krebs cycle both require NAD+ (and the Krebs cycle requires FAD), both of these processes stop running.

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