piuttonu tHIS polypeptide? 19-11 Two Types of Posttranslational Import. The mech
ID: 206442 • Letter: P
Question
piuttonu tHIS polypeptide? 19-11 Two Types of Posttranslational Import. The mechanis by which proteins synthesized in the cytosol are imported into the mitochondrial matrix is different from the mechanism by which proteins enter the nucleus, yet the two mechanisms do share some features. Indicate whether each of the following statements applies to nuclear import (Nu), mitochondrial import (M), both (B), or nei- ther (N). You may want to review the discussion of nuclear import i Chapter 16 before answering this question. (a) The polypeptide to be transported into the organelle has a specif short stretch of amino acids that targets the polypeptide to the organelle. and is cut off by a peptidase within the organelle. tein in the organelle's outer membrane. (b) The signal sequence is always at the polypeptide's N-terminus (c) The signal sequence is recognized and bound by a receptor pro- (d) ATP hydrolysis is known to be required for the translocation (e) GTP hydrolysis is known to be required for the translocation (1) Chaperone proteins are involved during translocation of the (g) The imported protein is transported in a membranous vesicle (h) The imported protein enters the organelle through a protein process process protein. prior to import. pore that consists of more than two dozen proteins and is large enough to be readily seen with the electron microscope.Explanation / Answer
A- Both
B. N - Both N-ter not cut by peptidase and also the sequence not only present in N-terminal
C. M - In nucleus Transporter receptor Importin binds with NLS sequence not the membrane receptor In mitochondria the sequence binds with TOM complex of membrane receptor.
D. M ATP-dependent import motor PAM is required
E. Nu RAN GTPase required for importin transport
F. M
G. N Neither
H. M - Mitochondria require lot of molecules to do process the protein to enter in to the matrix
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