piutein? Why? Gill nave on polo side chains ul ch thern ue is typically found in
ID: 148713 • Letter: P
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piutein? Why? Gill nave on polo side chains ul ch thern ue is typically found in the interior of a water-soluble cuiphc because they allou S b be bated in e nydodrobie co ern Gl 24. Explain why a denatured protein might not refold in vitro. 25, Describe t he difference between secondary and tertiary structure in proteins of main chaun ctom in Seiec hain. Tetiay Stuctkve: 3 denon sionel anonecment of all c 26. B-fibroin is a primarily constituent of silk. In your own words, describe the structure of e fibroin on the molecular level. 27. Why does NMR generate multiple, similar structures for a given protein? 28. Chaperones assist in what process! otein FoldingExplanation / Answer
Ans 24) In vitro the denatured proteins might not be able to regain back its structure or fold due to the precipitation, aggregation or due to irreversible covalent modification. Once it is denatured, it is not able to get back to the same conformation due to huge number of changes that occur possibly in the proteins.
Ans 26) The -fibroin is an insoluble protein which is present in the silk of the spiders and it consists of layers of antiparallel beta sheets. There is a recurrent sequence of amino acids in its primary structure which is Gly-Ser-Gly-Ala-Gly-Ala. The protein is packed tightly due to the presence of the glycine amino acid and helps in formation of the rigid structure of the protein.
Ans 27) NMR is able to generate multiple structure of a protein as it helps in decoding or finding out the tertiary structure of the protein. The basic principle behind the NMR is that many nuclei have spin with electrically charge. On application of an external magnetic field, there is an energy transfer that occurs between the base energy to a higher energy level.
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