Jennifer Lange, female, 25 years old was transfused with two units of type-speci
ID: 204598 • Letter: J
Question
Jennifer Lange, female, 25 years old was transfused with two units of type-specific crossmatched packed RBCs during an emergency surgery. After a day leaving the hospital, she was readmitted to the hospital for complications due to a drop of hemoglobin. A new type and screen were performed. LISS was used as an enhancement media. The results of the antibody screen test are below:
. What is another logical interpretation of these results based on the complications seen in the patient i.e. hemoglobin drop?
Screen Cell Immediate Spin 37oC AHG (polyspecific) SC I 0 0 3+ SC II 0 0 3+ Autocontrol 0 0 3+Explanation / Answer
The patient Jennifer Lange, female , 25 years of age was given blood transfusion in the laboratory after emergency surgery. The patient was examined after a day and the blood hemoglobin levels were checked, it was found that the blood hemoglobin levels have dropped. The anti-human globulin (AHG) polyspecific antibody testing was done for the red blood cells in the screens. The tests confirmed the generation of auto-antibodies in the body of the patient against the cell surface glycoproteins present on the surface of the red blood cells. The globulin proteins levels were raised in the plasma. The body has developed an auto-immune response against the foreign red blood cells that were transplanted. This has led to the autoimmune rejection response and immune rejection in the patient. The agglutination of the blood group antigen in the groups like lewis, e, d was confirmed by enzyme/NaCl method, spin saline tube experiments at 37oC, matrigel assays, and the LISS/Coomb's test. The results confirmed the blood group incompatibility. The direct and indirect Coomb's test was used for analyzing the reaction of the serum antibodies from the patient agglutinating with the donor red blood cells. The presence of aggregates confirmed the test results. It occurs in anemia and other blood related disorders.
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