A number of human-mouse somatic cell hybrid closes were examined for the presenc
ID: 202950 • Letter: A
Question
A number of human-mouse somatic cell hybrid closes were examined for the presence or human chromosomes and the expression of specific human genes. Part of the results are summarized in the table below. Assign each gene to the chromosome on which it is located. 2. (5 points) Hybrid Cell Lines 5 12 23 30 61 68 Genes Expressed HBB (defects causes Sickle Cell Anemia)++ CFTR (defects causes Cystic Fibrosis) BRCAI (defects causes Breast Ovarian Cancer) HEXA (defects causes Tay-Sachs Disease) ++ + LRRK2 (defects causes Parkinson's Disease)+ Chromosomes (Present or Absent) 16 17 18 19 20 21Explanation / Answer
HBB gene - present on Chromosome 11.
CFTR gene - present on Chromosome 7.
BRCA1 - present on Chromosome 17.
HEXA - present on Chromosome 15.
LRRK2 - present on Chromosome 12.
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