7. The pedigree below shows the inheritance of a rare human genetic disorder. A.

Question

7. The pedigree below shows the inheritance of a rare human genetic disorder. A. Does a dominant or recessive allele produce the trait? Explain. 2 points) B. Is it an autosomal or X-linked trait? Explain. (2 points) C. Use correct genetic symbols and give the genotype of the following individuals in the pedigree. (3 points) 1-2 1-3 D. What is the probability that individual III-1 is a carrier for this trait? (2 points) E. If individual III-1 marries a phenotypically normal womarn whose father had the disorder: (1) What is the probability they will have a child with the genetic disorder? (2 points) (2) What is the probability they will have either a female with the genetic disorder or a male that is phenotypically normal? (2 points)

Explanation / Answer

A. Recessive allele is producing the trait. This is because the allele is not present in all the male members of all the generation.

B. It is an X-linked trait. This is because if it was autosomal it would have been present equally in both the genders.

C. I-2 : XY; Y is normal and X is affected.

I-3 : XX; both XX are normal.

III-3 : XX; both XX are normal.

D. 50% probability is there that III-1 is a carrier.

E. If individual III-1 marries a women who is phenotypically normal whose father had the disorder, there are 50% chances that their son will be affected and daughters will be 100% affected.

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