Buchner, D.A., Charrier, A., Srinivasan, E., Wang, L., Paulsen, M.T., Ljungman,

Question

Buchner, D.A., Charrier, A., Srinivasan, E., Wang, L., Paulsen, M.T., Ljungman, M., Bridges, D., and Saltiel, A.R. 2015. Zinc Finger Protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. Journal of Biological Chemistry, 290: 6376-6386.

Above is link. It is article.

What hypothesis do the authors propose?

What is the role of GLUT4?

What is the relationship between GLUT4 function and type 2 diabetes?

What is ZFP407? How was it identified?

How did the authors demonstrate the role of ZFP407?

What is the significance of this study?

Explanation / Answer

Role of GLUT 4: GLUT4 helps in glucose uptake in peripheral tissues under influence of Insulin hormone.

Relationship between GLUT 4 and Type 2 diabetes: In type 2 diabetes GLUT 4 function gets disrupted that leads to hyperglycemia i.e more glucose in body fluids.

What is ZFP407? How was it identified?ZFP407 is a protein. It was identified through a targeted siRNA screen.

Role of ZFP407: it regulates many peroxisome proliferator activated receptor target genes and acts as a modulator of PPAR signaling pathway.

Significance of this study: It helps to understand type 2 diabetes and will help to find a cure for the disease through understanding of signaling pathway.

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