1. Explain the metabolic logic of insulin and glucagon regulation of glycogen me
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Question
1. Explain the metabolic logic of insulin and glucagon regulation of glycogen metabolism 2. At the beginning of class on Monday, we completed a diagram that showed the regulation of glycogen phosphorylase. Deconstruct this diagram to show the regulation of muscle glycogen phosphorylase and liver glycogen phosphorylase. 3. Using the diagrams you constructed for question 2, what is the metabolic logic that supports the observation that muscle and liver glycogen phosphorylase are differentially regulated by glucose and AMPExplanation / Answer
Metabolic logic of Insulin and Glucagon for the regulation of glycogen metabolism.
Insulin is secreted by beta cells of the islets of Langerhans in the pancreas, while the glucagon is secreted by alpha cells of the islets of Langerhans in the pancreas.
If the blood glucose level is higher, beta cells stimulate the release of insulin.
If the blood glucose level is lower, alpha cells secrete glucagon, which causes the liver to convert stored Glycogen into Glucose, and it is released in the blood stream.
Regulation of Muscle glycogen phosphorylase and Liver glycogen phosphorylase.
* Glucose inhibits liver glycogen phosphorylase but not the Muscle glycogen phosphorylase
* Ca2+ (trigger for muscle contraction) stimulates the muscle glycogen phosphorylase but not the liver glycogen phosphorylase
* Muscle glycogen phosphorylase is activated by AMP even when unphosphorylated.
BOTH Muscle glycogen phosphorylase and Liver glycogen phosphorylase catalyze the same reaction, but they are separate molecules (different regulatory mechanism).
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