5. Prader-Willi (PW) syndrome is a rare disorder that results in intellectual di

Question

5. Prader-Willi (PW) syndrome is a rare disorder that results in intellectual disability, a constant sense of hunger and obesity. This syndrome is caused by deletion or inactivation of seven genes that lie on Chromosome 15. Normally, these genes are INACTIVE on the maternally contributed chromosome, genes that should be expressed are not. Which one of the following "labels" best describes this observation. A) Gender related lack of commitment B Imprinting C) Chromosome delection D) Acetylation E Class switching

Explanation / Answer

Imprinting is the correct answer.

Reason: Genetic imprinting is a case in which genes expressed in a parent-of-origin-specific manner. It may be due to any epigenetic change like methylation, acetylation etc. This trait get "imprinted" in the germline of the parents that maintained throughout mitoticcell divisions in the somatic cells of an organism.

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