MOLECULAR BIOLOGY OF THE MARVELVERSE. DR. XAVIER, who has a PhD in molecular gen

Question

MOLECULAR BIOLOGY OF THE MARVELVERSE. DR. XAVIER, who has a PhD in molecular genetics, wants to bring you on board as a researcher to better understand the changes that lead mutants to their super abilities. In this SECOND part of the exam you demonstrate your expertise in the molecular biology of DNA repair to speculate about the capabilities of some well known mutants. Xmen heroine Rouge's ability manifests as a sucking away of life force when she touches another human. You hypothesize that her superpower causes oxidative damage in the cells of the person she has just touched. Your best friend has a crush on Rouge and has agreed to accompany her to the winter dance. Use your knowledge of recombinant DNA to superpower any repair pathway for your friend. In other words- a gain of function mutant in which DNA repair protein would save your friend from Rouge's touch? Gycoslases Ku heterodimers Rad51 XPC proteins

Explanation / Answer

I would choose RAD51 DNA repair mechanism, for saving my friend because it assist in DNA repair of double strand breaks. This protein family is highly conserved among all eukaryotes from yeast to human. In this way RAD51 proteins are functionally and structurally conserved. Another reason for choosing RAD51 protein is that, it is also known to have interaction with PALB2 and BRCA2, protein that is found to have significant to damage of DNA for the cellular response.

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