MOLECULAR BIOLOGY OF THE MARVELVERSE. DR. XAVIER, who has a PhD in molecular gen

Question

MOLECULAR BIOLOGY OF THE MARVELVERSE. DR. XAVIER, who has a PhD in molecular genetics, wants to bring you on board as a researcher to better understand the changes that lead mutants to their super abilities. In this SECOND part of the exam you demonstrate your expertise in the molecular biology of DNA repair to speculate about the capabilities of some well known mutants. You are invited to speculate about the amazing regenerative capacity of wolverine. And speculate that his cells may respond quickly to damage by replacing themselves all the time. How could an RTK pathway mutation in which Ras has a higher affinity for GTP than GDP. help Wolverine's cells replace themselves after injury.

Explanation / Answer

If RTK pathway mutation leads a higher affinity of Ras towards GTP than GDP, it will generate following signalling cascade.When Ras binds to GTP it will activates RAF which is a serine thronine kinase. RAF in turn will phophorylates ans activates MAPKK which will be next followed by activation of MAPK through phophorylation. Activated MAPK can inturn activates genes such as FOS, AP-1 . These genes can next activates other genes to regulate processes like cell proliferation, survival and migration. By this mechanism Wolverine cell could replace themselves after injury.

Related Questions

Navigate

• Browse (All)
• Browse M
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.