A screen has identified a mutant cell that is unable to migrate. Sequence analys

Question

A screen has identified a mutant cell that is unable to migrate. Sequence analysis reveals the presence of two mutations in the transmembrane domain of the Integrin alpha 6, that normally localizes to the plasma membrane, and which plays a critical role in cell adhesion.

The mutations are as follows: Leu --> Asp and Trp --> Lys.

Which of the following statements best describes the reason for why the mutant cell does not migrate in a fibronectin-coated dish?

The cell does not migrate because......

a)the cell cannot form desmosomes

b)the cell cannot form an adhesion belt

c)the cell cannot form the branched actin cytoskelton at the leading edge

d)the cell cannot adhere to the fibronectin that has been used to coat the dish

e)The cell is unable to link its actin to the ECM via cadherins

Explanation / Answer

d. the cell cannot adhere to the fibronectin

cells adhere to substrate through integrin. that play important role in cell movement.

due to mutation in integrin it cannot adhere

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