Answer all questions!!! Answer all questions!!! Describe the rationale for treat

Question

Answer all questions!!! Answer all questions!!! Describe the rationale for treating HIV Infection with combination therapy Give one examole of a regimen for a newly dagnosed patient. (You don't need to name specific drugs, just ose drug classes) One point for choosing a correct combination drug regimen and one point for choosing a correct description Two points max 2 two NRTis with boosted Protease Inhibitor D2 Integrase Inhibitors and 1 NRTI and 1 NNRTI 2 Protease hibitors and an Integrase lhbitor These regimens don't give rise to multiple mutations O These regisens have lower rates of mutations These regimens are well tolerated D These regimens are once daily in a combination plul form 2 NNRTs with Fusion inhbitor 2 NRTIs with an Integrase hbitor

Explanation / Answer

With help of combination treatment or therapy, it is possible to treat HIV infection and the combination of drugs or therapy helps in better treatment. The use of protease inhibitors along with two doses of NNRTI (Non-nucleoside reverse transcriptase inhibitors) is a great combination therapy for treating HIVs. The NNRTI bind to and blocks the HIV reverse transcriptase. The enzyme is mainly used by HIV to convert the RNA into DNA and hence when with aid of NNRTI, reverse transcriptase is blocked, it prevents HIV replication and preventing its spread. The protease inhibitor is a class of drugs which is very effective in preventing HIV and it prevents viral replication by binding selectively to viral proteases. This leads to blocking the cleavage of protein precursors that leads to production of the HIV causing viral particles or virus. Hence, combining the NNRTI with protease inhibitor prevents HIV due to enhanced combined effect.

The regime with use of NNRTI with protease inhibitor is great as it don’t give rise to multiple mutations. Using multiple therapy leads to unwanted mutations causing adverse affect.

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