Protein antigens of microbes that enter the body are captured primarily by _____
ID: 182435 • Letter: P
Question
Protein antigens of microbes that enter the body are captured primarily by _________ cells, and concentrated in the _________ lymphoid organs.
A.
neutrophil; peripheral
B.
dendritic; generative
C.
dendritic; peripheral
D.
phagocytic; peripheral
QUESTION 2
In every individual, different CD4+ and CD8+ clones can see peptides only when these peptides are displayed by that individual's MHC molecules. This property is called ________.
A.
clonal selection
B.
MHC restriction
C.
MHC activation
D.
clonal restriction
QUESTION 3
Which of the following cells is the most potent APC for activating naive T lymphocytes?
A.
dendritic cells
B.
plasma cells
C.
macrophages
D.
B cells
QUESTION 4
Which of the following properties does NOT describe class I MHC molecules?
A.
Class I MHC genes are codominantly expressed.
B.
Class I MHC molecules are expressed on all nucleated cells.
C.
Class I MHC molecules are expressed mainly on dendritic cells.
D.
Class I MHC genes are highly polymorphic.
QUESTION 5
All of the following properties describe class II MHC molecules EXCEPT:
A.
Class II MHC genes are co-dominantly expressed.
B.
Class II MHC genes are highly conserved among different individuals in a population.
C.
Class II MHC molecules are expressed mainly on dendritic cells, macrophages, and B lymphocytes.
D.
Class II MHC molecules consist of two chains, alpha and beta.
QUESTION 6
MHC molecules bind only _______ antigens.
A.
peptide
B.
whole protein
C.
lipid
D.
carbohydrate
QUESTION 7
These cells function in displaying antigens to activated B cells:
A.
macrophages
B.
dendritic cells
C.
follicular dendritic cells
D.
T lymphocytes
QUESTION 8
These cells can be induced by IFN-gamma and function mainly in the effector phase of cell-mediated immune responses:
A.
dendritic cells
B.
plasma cells
C.
B lymphocytes
D.
macrophages
QUESTION 9
In each individual, MHC molecules are capable of displaying which of the following kinds of peptides?
A.
individual's own peptides
B.
no peptides
C.
foreign or microbial peptides
D.
both A and C
QUESTION 10
Dendritic cells are capable of ingesting virus-infected cells and displaying viral antigens bound to class I MHC molecules to _____.
A.
CD4+ lymphocytes
B.
CD8+ lymphocytes
C.
NK cells
D.
B lymphocytes
A.
neutrophil; peripheral
B.
dendritic; generative
C.
dendritic; peripheral
D.
phagocytic; peripheral
Explanation / Answer
Answer:
1). C. dendritic; peripheral
Explanation:
Microbes are captured mainly by dendritic cells and concentrated in the peripheral lymphoid organs, where immune responses are initiated within 12 to 18 hours.
2). B. MHC restriction
Explanation:
MHC restriction refers to the fact that a given T cell can interact with both the self-major histocompatibility complex molecule and the foreign peptide that is bound to it, but will recognize and respond to the antigen, only when it is bound to a particular MHC molecule.
3). A. Dendritic cells
Explanation:
Dendritic cells undergo “maturation” to become potent antigen-presenting cells in lymphoid tissue.
4). C. Class I MHC molecules are expressed mainly on dendritic cells.
Explanation:
MHC class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and Bcells.
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