Figure 5, shows the fraction of compromised and non-compromised patients having
ID: 178543 • Letter: F
Question
Figure 5, shows the fraction of compromised and non-compromised patients having infections with different chromosomal virulence factors. Explain the graph, and suggest the pattern based on your knowledge of host defenses.
60 T 50 E 40 30 20 10 Number of Chromosomal Virulenc. Factors Present in Strain (P fimbriac, Aerobactin, or Homolysin) FIG. 5. Distribution of combined CVFs in strains from compro- mised and noncompromised patients. Patients were sorted by the presence or absence of compromising medical and urological con- ditions and further sorted by the number of CVF determinants present in the strains isolated from them (as described in the legend to Fig. 4). The fraction of each group of patients (compromised ln 47 or I.)In 11D associated with each cvF category (0 to 3) is shown.Explanation / Answer
Figure 4 needed to answer the question.
In noncompromised patients the more virulence factors lead to severe infection suggesting the participation of the immune response in fighting against the infection which can be seen in cases where low 0 or low (1) virulence factor is present. When 1 virulenc factor is present there are less patients who are infected indicating that many resolve the infection due to their own immune response.
In Compromised patients as the immunity is compromised presence of even 1 -2 virulence factors leads to infection in many people as they cannot resolve the infection.
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