A 50-year-old man presents because of a pruritic rash of several years\' duratio

Question

A 50-year-old man presents because of a pruritic rash of several years' duration. The rash is characterized by erythematous, eczematoid patches, and raised plaques and is distributed asymmetrically over the chest and abdomen. Biopsy of the plaques reveals atypical CD4+ T cells with cerebriform nuclei. Further marker studies lead to a diagnosis of mycosis fungoides. Which of the following is true of this disease?

Question options:

A)

The disease eventually disseminates to lymph nodes and internal organs

B)

The neoplastic cells most commonly display cell markers of CD19 and CD20.

C)

The skin rash most commonly disappears over time.

D)

This disease is caused by a chronic fungal infection in the skin.

E)

This is a benign condition and no further workup is necessary

A)

The disease eventually disseminates to lymph nodes and internal organs

B)

The neoplastic cells most commonly display cell markers of CD19 and CD20.

C)

The skin rash most commonly disappears over time.

D)

This disease is caused by a chronic fungal infection in the skin.

E)

This is a benign condition and no further workup is necessary

Explanation / Answer

It is also called Alibert-Bazin syndrome or granuloma fungoides. It is the most common form of cutaneous T-cell lymphoma. The cause is unknown. It causes unusual expression of CD4 cells. The disease dissiminates to the intenal organs and lymph nodes.

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