Genetics a)In the Batwa population, geneticists have identified a large effect l

Question

Genetics

a)In the Batwa population, geneticists have identified a large effect locus in the gene DOCK3 which affect height. Individuals with the CC genotype are 140 cm, CT genotype are 140.5 cm and the TT genotype are 146 cm.

b)Is the T allele recessive or dominant relative to the C allele? Circle the answer.

c)They genotyped the Batwa Pygmies and their taller neighbors the Bakiga, see below, and asked whether there is an overall correlation between Bakiga ancestry and height. Are admixed Batwa taller or shorter than individuals with ~0% Bakiga ancestry? Circle the answer.

d)Do you think DOCK3 is the only gene that determines height in the Batwa population? Why or why not? Explain with reference to trait complexity.

ADMIXTURE analysis of population structure (k 2) 1.0 a 0.5 0.0 Batwa individuals (n 169) -Bakiga (n 61)- Batwa males (n 66) Batwa females (n 103) 1801 r2- 023; 3.4x10 180 r2 0.31 p 1.4x10 06 170 170 o o 160 160 150 o o 140 140 130 0.0 0.2 0.4 0.6 0.8 1.0 0.0 0.2 0.4 0.6 0.8 1.0 ADMIXTURE ADMXTURE proportion of Bakiga ancestry proportion of Bakiga ancestry

Explanation / Answer

T allele is dominant than C allele.

Admixed Batwa are shorter than 0% Bakiga ancestry.

DOC3 is not the only gene that determines height. The height is also controlled by other factors like growth harmone etc.

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