Genetics Chromatin structure it dynamic In regions of highly condensed chromatin
ID: 54185 • Letter: G
Question
Genetics Chromatin structure it dynamic In regions of highly condensed chromatin. such as the centromere, the boundary between heterochromatin and euchromatin is variable. Genes that are near this boundary region can be influenced by cither type of chromatin what is referred to as position effects Recall the early Drosophila melanogoster experiments by Hermann Muller where the repositioning of the w * allele (normal activity of the w' allele produces red eye pigment) by translocation or inversion near this boundary of chromatin produced intermittent w * activity In the heterozygous state (w */w) a variegated eye is produced, with where and red patchesExplanation / Answer
All cells within the eye have the same genotype, so differences are attributed to epigenetic changes.
White patches in the eye are the result of silencing the w + allele by spreading of heterochromatin. On the other hand, when the heterochromatin does not spread into the w + allele, gene expression is normal, resulting in red patches in the eye. This results in a variegated eye phenotype.
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