The answer involves multiplying q by four and doing the pedigree, I just want to

Question

The answer involves multiplying q by four and doing the pedigree, I just want to know where the four comes from.

12. (14 points Recurrent polyserositis is an autosomal recessive genetic disorder. There are 16 children born with the condition per one million live births. This trait is in equilibrium. Zelda and Zane are considering having a child. They are related: Zelda's maternal grandmother (her mother's mother and Zane's paternal grandfather (his father's father are twins (sister and brother). No one in the family has the disorder a) What is the chance that Zelda and Zane's first child will have recurrent polyserositis due to inbreeding? Show your work and circle your answer.

Explanation / Answer

q2=16/1000000= (1.6x10-5)

q=1.6x10-5= 4x10-3 or 1/250

Chance of getting recurrent polyserositis due to inbreeding= q*4*(1/2)8

(1/250)*4*(1/256)=0.0000625=6.25x10-5

Here the 4 has taken as the both grandparents are siblings and to represent the second generation

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