A set of mice are each immunized with one of the following as shown in the Figur

Question

A set of mice are each immunized with one of the following as shown in the Figure below

Mouse A is immunized with tetanus toxoid protein. Mouse B is immunized with the Haemophilus influenzae type b polysaccharide antigen. Mouse C is immunized with a conjugate of the diphtheria toxoid protein linked to H. influenzae type b polysaccharide. Mouse D is left unimmunized (naive). Four weeks later the spleen cells from each mouse are isolated, and B lymphocytes and T lymphocytes from each spleen cell population are purified. When mixed together in culture together with a conjugate antigen of the tetanus toxoid protein linked to the to H. influenzae type b polysaccharide. Which of the following combinations of spleen cells would generate a memory B cell response?

Explanation / Answer

B: B lymphocytes from mouse A plus T lymphocytes from mouse A

Basically B cells will provide immune response, in this response T-helper cells also helps, however memory based immunity is provided by B cells only

B lynphocytes will identify normally toxoids and T cells will provide identification for remaining part of the peptide.

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