Question VIII. You are designing immunotherapeutic agents to treat tuberculosis,

Question

Question VIII. You are designing immunotherapeutic agents to treat tuberculosis, a disease that is caused by the intracellular bacterial pathogen Mycobacterium tuberculosis, which resides within endosomal vesicles of macrophages. Which of the following features of the immune response would you want your immunotherapeutic agent(s) to stimulate? Using your immunology knowledge, assess each statement (121-130) as either factually correct (true) or incorrect (false) in the context of the above-given description:

121. Production of acute phase proteins
122. Elevated levels of IL-4 production
123. Induction of the synthesis of complement membrane attack complex (MAC)

124. Elevated levels of IFN-g production
125. Induction of TH1 cells
126. Induction of TH2 cells
127. Elevated levels of megakaryocytes
128. Elevated levels of TGF-b production
129. Elevated levels of macrophage microbicidal activities
130. Induction of TB-specific, CD8+ CTLs

Explanation / Answer

121. True

Increased acute phase proteins from liver helps to inhibit the growth of microbs.

122. True

It is antiinflammatort cytokines helps to differentiate helper T-Cells.

123. True

124.True

IFN-g is an important activator of macrophages.

125.True

It provides cell mediated immunity.

126. True

It provides humoral immunity.

127. True

128. True

129. True

130.True

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