Link: http://www.nature.com/scitable/topicpage/genetics-and-statistical-analysis

Question

Link: http://www.nature.com/scitable/topicpage/genetics-and-statistical-analysis-34592

from the article, The ability to taste the chemical PTC is determined by a single gene in humans with the ability to taste given by the dominant allele T and inability to taste by the recessive allele t. Suppose two heterozygous tasters (Tt) have a large family (12offspring). Predict the proportion of their children who will be tasters and non-tasters. In the example given above, would the null hypothesis be extrinsic or intrinsic? Explain.

Explanation / Answer

Punnett square

...|.T..|.t..

T.|.TT.|.Tt.

t..|.Tt..|.tt.

25% TT, tasters

50% Tt, tasters

25% tt, non-tasters

Answer: 75% tasters

Tasters

There is a 75% chance (3:4, 3:4) that each child they have will be a taster, regardless of whether it is their 1st, 2nd, 3rd.....

Nontasters

The chances of a child being a non-taster is 25% (1:4)

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