Match the following phenotypes with the mutation that would be the most likely t

Question

Match the following phenotypes with the mutation that would be the most likely to be its cause. The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation. Try to answer each question by using the following reasoning: if you observe a _____ phenotype, then that could be due to a mutation in protein _____, in which the _____ domain has had an amino acid change from _____ to _____. Example: Q: _____ After a few rounds of cell replication, yeast cells die and their chromosomes are much shorter than those found in wild-type yeast. A: telomerase (the most likely protein mutated to give you this phenotype) _____ Mutant human cells die, and you observe that the DNA in the cells is not condensed prior to cell division _____ E. coli DNA replication does not take place, and you observe no single-stranded DNA in the mutant cells _____ In mutant E. coli, you observe Pol III core proteins floating freely in the cell, removed from the holoenzyme complex _____ In mutant E. coli, you see very low processivity and you observe high disassociation of Pol III and the DNA strand

Explanation / Answer

1. Condensins are the proteins which contribute to chromosome condensation.Mutations in condension may likely give this phenotypic result

2. Helicase protein is involved in unwinding the two strands during DNA replication. This is needed for initiation of replication. Mutation in the helicase might result in this response

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