Hello experts, l need your help with writing this case analysis draft Subject: O

Question

Hello experts, l need your help with writing this case analysis draft Subject: Offering hepatitis C livers for transplant waiting list patients who do not have hepatitis C It's not opinionated, its strictly based on researches and ethics hypothetical patient need to be created like a liver cirrhosis patient that's waiting for a liver and its urgent! Links will appreciate it if you can attach the scholarly peer reviews that will be used in the essay and all the other non scholarly websites as well (links of articles, scholarly websites), So l can printed and hand it to the professor please read the requirement l attached carefully Thank you so much!

Explanation / Answer

Infection with the hepatitis C virus (HCV) is an vital etiology of liver disease in patients with liver transplantation (Read AE, Donegan E, Lake J, Ferrell L, Galbraith C, Kuramoto IK, Zeldis JB, et al. Hepatitis C in patients undergoing liver transplantation. Ann Intern Med 1991;114:282-284). The basic cause of recurrence of hepatitis C infection is still unknown, following liver transplantation infection results in histologic hepatiis with allograft dysfunction are not demonstrated yet. Recurrence of HCV infection is demonstrated in early week after liver transplantation, developing HCV-induced cirrhosis and acute lobular hepatitis in early period of treatment. Pretransplant HCV infection is an important risk arise after development of posttransplant hepatitis. HCV infection accounts for the majority of posttransplant hepatitis not due to cytomegalovirus, and although many patients with posttransplant viremia have little evidence of histologic hepatitis, significant hepatic damage may occur (Wright, T. L., Donegan, E., Hsu, H. H., Ferrell, L., Lake, J. R., Kim, M., ... & Greenberg, H. B. (1992). Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology, 103(1), 317-322.). data shows a detrimental effect during matching the liver of donor and recipient for the HLA-DQB antigen, due to association with a recrudescence of chronic hepatitis. Certain HCV genotypes cause severe diseses after liver transplantation, but reports are not so convincing rather contradictory. The study show the relation of HLA mismatches between donors and recipients and viral genotypes to the severity of recurrent disease in the graft (Gane, E. J., Portmann, B. C., Naoumov, N. V., Smith, H. M., Underhill, J. A., Donaldson, P. T., ... & Williams, R. (1996). Long-term outcome of hepatitis C infection after liver transplantation. New England Journal of Medicine, 334(13), 815-821)

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