FGF2 can bind to both FGFR1c and to heparan sulfate proteoglycans (HSPGs) simult

Question

FGF2 can bind to both FGFR1c and to heparan sulfate proteoglycans (HSPGs) simultaneously. The bi nding of FGF2 to FGFR1c has a K D = 10 nM, a nd the binding of FGF2 to HSPGs has a K D = 2 00 nM. The forward binding rate constant (k f ) for binding of FGF2 to either FGFR1c or HSPG is the same and is equal to 1 x 10 6 M - 1 min - 1 whereas the k f for binding of FGF2 to both FGFR1c and HSPG simultaneously is equal to 2 x 10 6 M - 1 min - 1 . Based on this information what might the K D for the simultaneous binding of FGF2 to FGFR1c and HSPG be? Explain your answer

Explanation / Answer

FGF2 is Fibroblast Growth Factor 2 in human (Homo sapiens) which binds to FGFR1 is Fibroblast Growth Factor Receptor. KD value tells about the dissociation rate that is how quikly it dissociates from its antigen, to the antibody association rate of the antibody that is how quickly it binds to its antigen. in general we can say it is opposite to the antibody affinity. So according to the query mentioned, the FGF2 dissociation rate from its receptor FGFR1 is 10 nM. this application is used in drug designing process.

conclusion from the relationship between binding and KD is that they both are directly proportional to each other, firstly it increases then it becomes constant on achieving optimum vaue.

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