4) List the basic steps to performing a GWAS. can someone help with this? Wasted

ID: 150783 • Letter: 4

Question

4) List the basic steps to performing a GWAS.

can someone help with this? Wasted three questions. was given websites that did not help

Missed class regarding basic steps to performing a GWAS

Found this on the internet

Step 1: Variant identification (sequencing)

Step 2: Population stratification

Step 3: Statistical tests

Step 4: Examine local region

Step 5: Annotation

this is my classmates notes:

Genome wide Associated sequence

Can only do with second generation

Sort samples by phenotype of interest

Use 2nd generation sequence to examine millions of loci locus regions of DNA

Sort alleles based on how they occur with phenotypes

Calculate L.O.D (likely-hood of disequilibrium)

This was answered by Chegg question

1. Phenotype - is there scientific or clinical significance

2. Subject- sample size, structure, power

3. Diagnosis- objective measure

4. Sample- DNA specimen from blood or tissue

5. Genotyping- millions of SNPs, platform to check

6. Association- effect size and significance

7. QC - quality controls to reduce false positives 8. Results- logical, clear, concise results

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