1. You have a cell and you know the concentrations of some ions, but not the oth

Question

1. You have a cell and you know the concentrations of some ions, but not the others. Na] IK-1 CI-] (A-1 Calculate the concentration of the unknown ions based on the following: Intracellular Fluid] [Extracellular Fluidlo ? mM 142 mM mM 127 mM 135 mM ? mM 140 mM 2mM I neutrality to determine [K.le b) Use the Donnan rule to calculate [CI] c) You know osmolarity is balanced, so use that to determine [Na-lu d.) Based on your identification of each ion concentration, what is the driving force for Na+ if K is 25 times more permeable than Na+?

Explanation / Answer

For a., Since the membrane is at resting stage , therefore based in the equation Eion= RT/zF log( K+ extra/K+ intra), which gives a value of 9.67 mM for [K+].

b. based on donnan rule, Ko/Ki = Ci / Co, which gives a value of 9.534 mM for [Cl-] intracellular

c. to maintain osmolarity, both the intra cellular and extracellular ( total concentration of K+, Na+, and Cl- ) should be equal, so. [Na+] is 133.14

d. the driving force for Na+ if K+ concentration is more than Na+ , is Na-K pump.

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