Figure 1: Figure 2: Relevant Information concerning GW: Answers for Questions 2-

Question

Figure 1: Figure 2: Relevant Information concerning GW: Answers for Questions 2-4: WT Sed WTEX * Sed Ex PDmKO Ex Ex WT PDmKO WT PDmKO C OCR-Palmitate Pdk4 10 Sed Ex 30 pt1 Pdh 10 20 B-Ox-TCA ATP 10 OXPHOS WT PDmKO WT PDmkO WT PDmKO G Running time 4001 Sed Ex 300 00072 0.00021 * 200 100 ." a. s WT PDmKO Run distance on treadmi disance on breadrn. Im( Activity 24h [counts/h) Gastrocnemus mass % Figure 1. Exercise Induces a PPAR8-Dependent Shift in Muscle Energy Substrate Utilization Experiments were performed in the same set of 4-month-old wT or POm KO mice with or without 4 weeks of exercise training (n A) Oxygen consumption rate (OCR, VO2) and respiratory exchange ratio (RER, VCO,NO) measured over a 48 hr pariod (B) Quantitative analysis of VO, and RER using area under curve (AUC) of the data in () (C) OCR using palmitoyl-carnitine as the substrate in freshly isolated mitochandria from quadriceps muscle. (D) Diagram showing the two major types of fuel sources (glucose and FAs) and the gatekeeper enzymes that control their mitochondrial infiux E and F) mRNA expression levels of (E) Cpttb and (F) Pdk4 in soleus. (G) Total running time in a run-to-oxhaustion endurance test -) Correlations between PPARS expression in quadriceps and running distance, activity, and muscle mass. Asterisks denote statistically significant differences (p

Explanation / Answer

13) Figure 1. and Figure 2. are partially similar that is graphs E and F matching with graphs F and I of figure 2.

15) The GW is acting like a supplement to boost Fatty acid metabolism and Muscle Activator in a sedentory mice exhibiting similar effect of a mice with active excercise.

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