A molecule with a shape that is exactly molecule with a shape that is exactly co

Question

A molecule with a shape that is exactly molecule with a shape that is exactly complementary to the substratclactive ste of an emay 8. will a. increase the rate of the reaction. b. decrease the rate of the reaction. c. have no effect on the rate of the reaction d. change the equilibrium constant for the reaction. e. none of the above. d. serine, threonine, and isoleucine e. serine, tryptophan, and alanine 9. Which group consists only of amino acids with polar side chains? a. b. c. serine, threonine, and leucine serine, threonine, and cysteine serine, threonine, and valine 10. Which of the following interactions play no role in stabilizing tertiary and/or quaternary structure? a. Hydrophobic interactions c. Hydrogen bonds d. Covalent bonds They all play a role e. b. Electrostatic interactions I1. Which of the following classes of enzymes catalyze reactions involving the cleavage of a bond by the addition of water across the bond? a. Transferase b. Hydrolase c.Lyase d. Ligase e. Isomerase 12. Given the R-groups in the peptide, Asp-Gln-Arg-Ser-His, it would likely be: a. Very water soluble b. Somewhat water soluble c. Not very water soluble d. Not soluble at all e. Cannot tell from the sequence 13. Which of the following amino acids is least likely to take part in the catalysis of a nucleophilic reaction? a. Serine b. Threonine c. Tyrosine d. Glycine e. Glutamate 14. Which statement is incorrect about prions? The cellular form of the prion protein (PrP) contains little to no structure. a. b. The abnormal prion protein (PrP*) contains about 50% ß structure. c. PrPse is resistant to denaturation and proteases. d. PrPC is the "infectious" particle. e. PrP& catalyzes the abnormal folding of PrPC 15. Substrates bind to allosteric enzymes in a cooperative manner. Which of the following statemer regarding cooperative substrate binding is true? a. Two or more proteins aid the binding of a substrate. b. The binding of one substrate makes it easier to bind the second and subsequent substrate molecules. c. The folding of part of a protein aids in the folding of the remainder of the protein d. All enzymes engage in cooperative binding, not just allosteric enzymes. The binding of a cofactor to a protein aids in the binding of a substrate. e.

Explanation / Answer

8) A molecule which has shape exactly similar to the substrate and complementary to the active site of enzyme binds to the active site of the enzyme and this molecule can be called as Competitive inhibitor.

Binding of Competitive inhibitors (c) have no effect on the rate of the reaction. It only increases the Km of the reaction.

9) Six amino acids which have side chains that are polar but not charged are serine (Ser), threonine (Thr), cysteine (Cys), asparagine (Asn), glutamine (Gln), and tyrosine (Tyr).

So the correct option would be (b) Serine, Threonine and Cysteine.

10) There are different types of bonding interactions which stabilize the tertiary structure of proteins including: hydrogen bonding, salt bridges (electrostatic interactions), disulfide bonds, and non-polar hydrophobic interactions.

Disulfide bonds which are actually the covalent bonds and are formed by the oxidation of the sulfhydryl groups on cysteine residues of the polypeptide chains.

So, option (e) They all play a role would be the correct option.

11) Hydrolases are the hydrolytic enzymes that use water to cleave the chemical bonds and divides a large molecule into smaller molecules. Examples of common hydrolases are proteases, glycosidases, lipases etc.

The correct option is (b) Hydrolase.

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