Help me to interpret this. Thank you IL-1R1 did not appear to be needed in the l
ID: 147061 • Letter: H
Question
Help me to interpret this. Thank you
IL-1R1 did not appear to be needed in the lungs is that the lungs in the control B6 mice were rendered functionally IL1 deficient by an abundance of IL-Ra, amounting to >300-fold excess of IL-1Ra over IL-1Beta in the BALF
Help me to interpret this. Thank you
IL-1R1 did not appear to be needed in the lungs is that the lungs in the control B6 mice were rendered functionally IL1 deficient by an abundance of IL-Ra, amounting to >300-fold excess of IL-1Ra over IL-1Beta in the BALF
Help me to interpret this. Thank you
Explanation / Answer
The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1 receptor 1 and the common adaptor for toll/IL-1R signal transduction, MyD88, in this process using a murine model of acute pulmonary injury. bleomycin insult result in expression of neutrophil anf lymphocyte chemotactic factirs, chronic inflammation, remodeling, and fibrosis.we demonstrate that thses end points were attenuated in the lungs of IL-1R1- and my D88- deficient mice. futher, in bone marrow chimera experiments, bleomycin-induced inflammation required, bleomycin-induced inflammation required primarily myD88 signaling from radioresistant resident cells.
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