This is a pharmacology question. Please help me and answer it in a way that I ca

Question

This is a pharmacology question. Please help me and answer it in a way that I can understand it and do lt myself next time. but with select subject site there is no pharmacology there so I decided to select biology for me to able to post it. but is not biology but is pharmacology. Thank you.

Chloramphenicol is a clinically useful antibiotic with the following chemical structure The The concentration of chloramphenicol added to b ways compound is uncharged over the pH range 2-9 and is poorly soluble in water iological fluids may be determined in several Bioa ssay determination of the capacity of a sample to inhibit growth of microorganisms in vitro as compared to the capacity of a series of standards containing known a chloramphenicol. Biotransformation products of chloramphenicol, produced in man and perimental animals, are inactive against microorganisms, so a bioassay of a sample containing both chloramphenicol and its metabolites measures unchanged chior only (Why would such an assay for chloramphenicol possibly be inappropriate in a patient receiving multiple antibiotic agents?) al assay for nitro groups NO2 groups are not present in mammalian fluids, so a l assay for this substituent can be used to quantitate chloramphenicol. But there is a . Chemic problem with the derivatives of chloramphenicol formed in vivo in which the molecule are modified (Where might this molecule be modified? HINT Might the aliphatic hydroxyl group be a site for glucuronide conjugation?) accuracy, specifically the validity, of this assay because it detects all NO2 remains but other parts of the

Explanation / Answer

1. B. first orer kinetics

2.neither of the above

3.none of th above

4. total body water

5. option D

6. option A

7.option A

8.option B

9. option B

10. option B

11.option A

12. option B

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