Uniden’s condition is an X-linked recessive trait in the Redialer population. Th
ID: 132825 • Letter: U
Question
Uniden’s condition is an X-linked recessive trait in the Redialer population. The trait allele F has a frequency of 0.005 in this population; that is. the frequency is the same in the male and female populations. Individuals with this trait have a strong desire to use land-line phones. Note, the trait gene is in Hardy Weinberg Equilibrium (HWE) for the female Redialer population.
An man with the trait and an woman without the trait have a son. What is the probability that the son has Uniden's condition?
(Hint: Use the HWE equation to determine the most likely genotype in the woman).
A. 1E-05.
B. 0.5
C. 0.0
D. 0.25
E. 0.005.
Explanation / Answer
Unidens condition is a X linked recessive trait. A man with the trait and s woman without the trait have a son.
The frequency of F allele is 0.005. Therefore, the frequency of f allele is 0.995. The frequency of individuals with different genotypes are as follows,
FF = (0.005)*0.005) = 0.000025
F f = 2(0.005)(0.995) = 0.00995
f f = (0.995)(0.995) = 0.99
Man with the trait and woman without the trait have the disease. The probability of having an affected son is 0.25.
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